Pharmacology of the blood
Last lecture we talked about thromboembolic disorders (pathologicdisorders).
Physiological thrombus: is important to stop bleeding.
Pathological thrombus: diseases like:
DVT (deep venous thrombosis).
PE (pulmonary embolism).
MI (myocardial Infarction).These are known as
in which we try toprevent thrombosis by different mechanisms:1.
Drugs that inhibit platelet aggregation and adhesiveness. Plateletsplay an important role for thrombus or clot formation.2.
Drugs that inhibit the action of the clotting factors.
Either drugs that are given parenterally (E.g., heparin), it will activate antithrombin III which is an endogenousprotease which activity is increased by heparin.)Antithrombin III will cause degradation of thrombin IIa andX.
Or drugs that are given orally (E.g., warfarin). Another typeof anticoagulants and it inhibits the synthesis of vitamin k dependent clotting factors. It has a delayed onset of actionbecause its site of action is in the liver, its effect is seen afterthe already synthesized clotting factors are depleted, and bythat it has a delayed onset of action. It is not used duringpregnancy because it can cross the placenta(teratogenicity).