There are two types of diabetes and pre-diabetes as topics of interest. Type one diabetes is characterized by the destruction of the insulin-secreting B-cells of the pancreas. It can be characterized as an auto-immune disease. Type two diabetes is caused by the malfunction of the B-cells of the pancreas and the pathological condition where the cells fails to respond to insulin concentrations appropriately known as insulin resistance. A natural treatment for type 2 diabetes is exercise. Exercise increases glucose uptake immediately and increases the glucose uptake stimulated by insulin in the following days after exercise. A sedentary lifestyle is a risk factor for type 2 diabetes. In contrast, a high activity level reduces the risk of type 2 diabetes significantly. Studies have found that exercise will increase glucose uptake despite insulin-stimulated glucose uptake being impaired in type 2 diabetics. As a general rule of thumb, the greater the intensity of the exercise, and the longer the duration, the greater the uptake of glucose into the skeletal muscle will be. AMPK and CaMKs both regulate exercise-stimulated glucose uptake independent of insulin, and both are elevated during exercise when glycogen depletion is sensed and calcium is released during skeletal muscle contraction. Another important point is that insulin sensitivity is enhanced for several days. As we can see, it’s vital that diabetes is recognized as a treatable disease through exercise.