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Any HIV cure on the horizon will have to tackle macrophage immune cells as well as CD4 T Cells, a study indicates.
HIV cure research has principally focused on latently infected CD4 cells as the backbone of the viral reservoir.
Researchers believe that macrophage cells in the liver that harbor such inert HIV are not a part of the viral reservoir.
Researchers have discovered how HIV manages to infect macrophage immune cells, which can be a key part of the viral reservoir.
Researchers have found that in addition to CD4s, macrophage cells can harbor HIV even in the face of antiretroviral treatment.
A protein that normally blocks HIV from infecting the immune cells naturally deactivates for small windows of time.
HIV damages the brain by infecting white blood cells that enter the organ and set off a harmful immune response.
Researchers have had early success in a method that might one day thwart the powerful blood-brain barrier and effectively deliver.
Researchers have discovered the regulation process for a protein that prevents HIV from making copies of itself in white blood cells.
The brain is a reservoir for HIV, where the virus develops brain-specific mutations that may make it more virulent.
Stumbled upon the mechanism in which some immune system cells keep HIV from hijacking their cellular machinery to produce new virus.
For the first time, researchers have shown that HIV can actively reproduce in a cell type other than CD4 cells.
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