In this article, computational fluid dynamics(CFD) method is used to predict the effect of blade numbers on the pressure drop of axial cyclone separators. A three-dimensional model is built to acquire the resistance of axial cyclone separators with different blade numbers. The flow field inside cyclone separators is calculated using 3D Reynolds-averaged Navier-Stokes equations. And turbulence model is used to simulate the Reynold stress. Also pressure drop of cyclone separators with different blade numbers is expressed as a function of different inlet velocities. At the same inlet velocity with increasing the blade numbers, pressure drops of cyclones reduce greatly. And changing the blade number of cyclone separator is an effective method to improve its resistance performance.