In high stress situations like making a goal in soccer, some athletes go through a quick slump in performance under pressure, known as “choking.” Now, Salk Institute researchers have uncovered what might be behind the phenomenon - one-way signals from the brain’s emotion circuit to the movement circuit.
The research could lead to new strategies for treating disorders with disrupted movement, such as depression, obsessive-compulsive disorder, and anxiety, along with aiding in recovery from spinal cord injuries or physical performance under pressure.
“This finding is very exciting as it is the first time that a comprehensive circuit mechanism has been found showing how emotional states can influence movement through connections in an area of the brain called the basal ganglia, a region involved in guiding behavior. We did not previously know much about this pathway, so it brings about a whole new paradigm for examining psychiatric disorders as well as spinal cord injury,"
senior author Associate Professor Xin Jin says.
Parallel Closed Circuits?
It was previously believed that the brain’s emotion and movement loops worked like parallel closed circuits, operating independently to relay important information. However, researchers suspected that there could be some influence of emotion on movement due to the observation that, in neuropsychiatric conditions such as depression, decreased physical movement is a symptom and could be linked to disrupted emotional processing and reduced motivation.
Yet, scientists did not know much about the connections within each circuit or how the circuits might interact.
“We wanted to explore how emotion information reaches the movement circuitry in the brain by using a combination of cutting-edge viral and optogenetic techniques,"
says Sho Aoki, co-first author and postdoctoral fellow in the Jin lab.
One-way Communication Path
The scientists sought to trace these circuits in rodent models to better understand each step of neuronal communication. They focused on the emotion and movement brain loops, starting from a region involved in emotion (the medial prefrontal cortex) and a region involved in movement (the primary motor cortex).
They used multiple genetic and viral tracing tools, including a technique developed by Salk Professor Ed Callaway’s lab, to observe how each loop was organized in the brain.
[caption id=“attachment_100073” align=“aligncenter” width=“700”] Subcircuit-specific modified rabies tracing confirms limbic-to-motor connectivity through the direct pathway.
Credit: Sho Aoki, et al. CC-BY[/caption]
To the researchers' surprise, they found a one-way communication pathway from the emotion loop to the movement loop through an area located deep in the brain called the basal ganglia. The basal ganglia, which includes structures involved in guiding behavior, essentially acts as a crossroads for the emotion circuit to directly influence the movement circuit to control action.
To confirm their results, the authors used optogenetics, a technique that uses light to control cells, to investigate the precise function of the neurons in this region. They also studied each neural circuit in isolation from the rest of the brain and confirmed the novel pathway.
“Psychiatric diseases such as depression and anxiety can alter actions in a dramatic way by either decreasing or increasing movement. This mechanism represents a likely way that emotional states are related to changes in action control in psychiatric diseases,"
Spinal Cord Injury
Additionally, this unidirectional communication may be relevant for recovery from spinal cord injury. Researchers previously focused on movement centers of the brain because spinal cord injury is a movement issue; however, since these results suggest emotional states can influence brain movement centers, experiencing positive emotions such as motivation may aid patients in the recovery process.
Activating emotion centers could likewise stimulate movement centers and facilitate recovery, according to the Salk co-first authors Jared Smith, a postdoctoral fellow, and Hao Li, a senior research associate.
Further, these results suggest that emotional states could directly influence sports performance. So, Jin advises, maybe the next time you feel anxious during a game, just calm down and let the action take care of itself.
 Sho Aoki, Jared B Smith, Hao Li, Xunyi Yan, Masakazu Igarashi, Patrice Coulon, Jeffery R Wickens, Tom JH Ruigrok, Xin Jin. An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway. eLife 2019;8:e49995 DOI: 10.7554/eLife.49995
 G E Alexander, M R DeLong, P L Strick. Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex. Annual Review of Neuroscience. Vol. 9:357-381 (Volume publication date March 1986) https://doi.org/10.1146/annurev.ne.09.030186.002041