|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|kid lgi||kid lgi liv||kid||liv||72.5m,v||47.7m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
BROMODICHLOROMETHANE (dichlorobromomethane) 75-27-4 852 M f b6c gav 24m24 TR321 : 0 52.0mg 104.mg liv MXA 28.9mg * P<.0005 c 18.6mg 52.2mg 3/50 18/50 29/50 liv:hpa,hpc. liv hpa 36.0mg * P<.0005 c 22.8mg 65.0mg 1/50 13/50 23/50 liv hpc 144.mg * P<.002 c 69.9mg 734.mg 2/50 5/50 10/50 MXA mlh 132.mg \ P<.02 47.5mg n.s.s. 2/50 7/50 (1/50) mul:mlh; spl:mlh. S TBA MXB 62.9mg * P<.04 26.3mg n.s.s. 34/50 31/50 35/50 liv MXB 28.9mg * P<.0005 18.6mg 52.2mg 3/50 18/50 29/50 liv:hpa,hpc,nnd. lun MXB 644.mg * P<.2 176.mg n.s.s. 1/50 2/50 3/50 lun:a/a,a/c. 853 M m b6c gav 24m24 TR321 : 0 17.5mg 35.0mg mul mlp 74.2mg \ P<.008 28.1mg 1.51gm 0/50 5/50 (3/50) S kid MXA 137.mg * P<.02 c 61.8mg n.s.s. 1/50 2/50 9/50 kid:tla,uac. kid tla 215.mg * P<.09 c 80.4mg n.s.s. 1/50 2/50 6/50 kid uac 336.mg * P<.03 c 116.mg n.s.s. 0/50 0/50 4/50 TBA MXB no dre P=1. 42.5mg n.s.s. 38/50 36/50 35/50 liv MXB no dre P=1. 51.4mg n.s.s. 17/50 16/50 20/50 liv:hpa,hpc,nnd. lun MXB no dre P=1. 158.mg n.s.s. 12/50 3/50 7/50 lun:a/a,a/c. 854 R f f34 gav 24m24 TR321 : 0 34.7mg 70.1mg MXB MXB 84.8mg / P<.0005 52.7mg 150.mg 0/50 1/50 24/50 col:acn,apn; kid:tla,uac. C kid MXA 143.mg * P<.0005 c 79.8mg 294.mg 0/50 1/50 15/50 kid:tla,uac. col MXA 200.mg / P<.0005 c 103.mg 505.mg 0/50 0/50 12/50 col:acn,apn. kid uac 272.mg * P<.002 c 128.mg 934.mg 0/50 0/50 9/50 kid tla 351.mg * P<.008 c 152.mg 5.11gm 0/50 1/50 6/50 col apn 364.mg * P<.004 c 157.mg 2.04gm 0/50 0/50 7/50 col acn 411.mg * P<.007 c 168.mg 4.92gm 0/50 0/50 6/50 TBA MXB no dre P=1. 73.5mg n.s.s. 48/50 43/50 43/50 liv MXB no dre P=1. 303.mg n.s.s. 1/50 3/50 1/50 liv:hpa,hpc,nnd. 855 R m f34 gav 24m24 TR321 : 0 35.0mg 70.1mg MXB MXB 30.3mg / P<.0005 21.7mg 43.8mg 0/50 13/50 46/50 col:acn,apn; kid:tla,uac; rec:acn,apn. C MXA MXA 30.7mg / P<.0005 c 22.0mg 44.5mg 0/50 13/50 45/50 col:acn,apn; rec:acn,apn. MXA acn 35.6mg / P<.0005 c 24.9mg 53.3mg 0/50 11/50 38/50 col:acn; rec:acn. MXA apn 55.6mg / P<.0005 c 36.8mg 89.2mg 0/50 3/50 33/50 col:apn; rec:apn. kid MXA 152.mg / P<.0005 c 81.6mg 345.mg 0/50 1/50 13/50 kid:tla,uac. kid uac 213.mg / P<.0005 c 103.mg 603.mg 0/50 0/50 10/50 tnv men 350.mg * P<.05 143.mg n.s.s. 0/50 3/50 3/50 S lun MXA 366.mg * P<.02 149.mg n.s.s. 0/50 2/50 4/50 lun:a/a,a/c. S lun a/a 447.mg * P<.05 169.mg n.s.s. 0/50 2/50 3/50 S kid tla 583.mg * P<.05 c 201.mg n.s.s. 0/50 1/50 3/50 TBA MXB 267.mg * P<.7 37.0mg n.s.s. 43/50 41/50 47/50 liv MXB 747.mg * P<.2 207.mg n.s.s. 1/50 0/50 4/50 liv:hpa,hpc,nnd. 856 R f wis wat 43m43 1681 0 94.9mg Tumasonis;eaes,9,233-240;1985 liv nnd ev 544.mg P<.002 + 307.mg 1.51gm 0/18 17/53 857 R m wis wat 42m42 1681 0 83.7mg pit tum ev 911.mg P<.06 382.mg n.s.s. 1/22 10/47 liv nnd ev no dre P=1. 920.mg n.s.s. 5/22 6/47
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.