The patients were over the age of 12 and had a lung function between 50 per cent and 90 per cent of healthy individuals.
Some said they felt better and were able to clear the mucus from their lungs, while others reported no improvement, said Professor Jane Davies of Imperial College, a member of the consortium.
Prunes, apples, peaches, and sugar-free foods, for instance, contain sorbitol.
However, the members of the UK Cystic Fibrosis Gene Therapy Consortium believe they have now made the key initial breakthrough that allows them to proceed with further clinical trials involving more active forms of the gene-therapy treatment.“We are looking to undertake follow-up studies assessing higher, more frequent doses as well as combinations with other treatments,” Professor Alton said.
The latest trial involved 40-minute inhalations once a month for year with a nebulising spray containing fatty droplets or “liposomes” wrapped around a healthy, synthetic copy of the cystic fibrosis gene.
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