14-Sep-2021 | Market Research Store
The Tel-Aviv University researchers have recently published a white paper that uncovers the very first 3D printed model of glioblastoma – which is often considered the deadliest form of brain cancer. The team quote that they used human glioblastoma tissues that contained the primary component of the malignant tumor as the printing component for their 3D printed adventure. The team hopes that the breakthrough in research is expected to pave the way for a wider range of treatments for patients and accelerate the developmental process of newer drugs and further discover a new form of druggable markers.
The 3D-printed models are based on samples that were acquired from patients and were taken directly from the Tel Aviv Sourasky Medical Center.In a previous study, the team identified a new form of protein known as P-Selectin which is produced when glioblastoma cancer cells interact with microglia – cells that are pertinent in the immune system of the brain. The team further quote that they associated this form of protein responsible for the failure of the microglia which leads to them to attack the deadly set of cells, which further pertains to the cancer being spread in a rapid manner. The team identifies all the current set of issues related to the protein after it is removed during surgery, but how the same results were observed when the glioblastoma cells were grown in a 2D form in a lab.
The reason that the team suggest for this failure can be pointed to the effect of a plastic surface being extremely different in providing a reaction to the human anatomy. The team further quotes that 90% of all experimental drugs fail at the clinical trial stage because the same effect cannot be achieved for a lab grown virus as the same feature will not survive in a real patient.