A. hydrophila hydrophilia is frequently encountered in the human gastrointestinal tract, but instances of A. hydrophila bacteremia are rare. During the last decade, the medical literature attests to the high mortality rate among immunocompromised patients who undergo extraintestinal Aeromonas infections, and it is thus important to be aware of the variable presentation in this infection. While Aeromonas is often associated with fresh water exposure, only one of these eight patients presented with this history. The fact that Aeromonas infection can arise in immunocompromised patients without a recollection or history of exposure to contaminated water is of paramount importance in appropriately considering Aeromonas among the differential diagnoses. Liver damage was also found to be an important factor in many of these patients, and cirrhosis is discussed as a possible predisposing factor for septicemia.