Under ordinary circumstances, your body has two primary ways of neutralizing catechol and quinone estrogens. As we mentioned above, the methylacion process immediately takes care of probably 99 percent of the catechol estrogens with an enzyme called catechol ortho-methyltransferase (COMT). Red blood cells have some of the highest levels of this enzyme, and every tissue of the body is lined with it to protect it from the formation of catechols within or from incoming catechols. If this weren’t so, the catechols such as quercetin that are found abundantly in many foods would be toxic. Methylation by COMT effectively renders the estrogens inert and targets them for elimination though bile (feces), urine or sweat.
The mythylatio pathway can become overwhelmed under certain conditions in the body, allowing some of the 2- and 4-hydoxy estrogens to slip through the cracks and survive intact. Some of the conditions that can block the methylation pathway include:
· A genetic flaw in the production of COMT
· Nutritional deficiencies that result in limited availability of methyl groups for the enzyme
· Excess production of estrogens
Scientists have shown in animals that certain chemicals, when oxidized, will more readily strip the catechol or electrons and transform it into a quinone. For example, a combination of a peroxidase enzyme (which happens to be induced by estrogens) and rancid fats or oils will activate the bad estrogens. These unstable lipids often come from the polyunsaturated oils such as corn and safflower oil.
Flax seed oil is one of the most unstable and unsaturated oils we know of, which is why we are not keen on over-using it as a nutritional supplement. (It’s okay to grind the seeds and use those in moderation.) Mother Nature put these oils in our foods in small amounts for a good reason! Saturated fats such as those found in eat and coconut oil do not oxidize this way. So much for the nutritional wisdom doled out by the government and the processed foods industry for the past four decades" Page 125-126 What Your Doctor May Not Tell You About Breast Cancer, How Hormone Balance Can Help Save Your Life, John R. Lee, MD, David Zava, Virginia Hopkins. 2003, ISBN 0-446-52686-X
I researched natural antihistamines for and discovered quercetin. Recently I hastily purchased a bottle of quercetin in plastic capsule form. I try to avoid ingesting plastic whenever possible. Just for the first dose, I popped the pill, along with my Vitamin C. I noticed that my allergies very mild (and right during prime allergy time for me). I decided, though, that it may be a good idea to open the capsule and pour the contents into water, thus avoiding ingestation of plastic; this I tried today. After just a few sips, I noticed a wave of sensations over most of my face. Since I was about to go out for the evening, I didn't want to have an unexpected reaction and decided not to finish the drinking the dose. Then, something curious happened: my plugged up right ear that has been giving my problems for a couple of years now suddenly started to pop open a little. The feeling was terrific! It did not fully clear up, but you have to remember that this was not a full dose. I also noticed that I could breath easier and my asthma was non-existent.
Since I have never experienced this effect before, so quickly, and all at once, I immediately conisidered that taking the quercetin dose orally in water had a much more powerful and sudden absorbtion into my body. I was somewhat concerned about the intensity of the effect, which cause me to not finish the dose, but I am very optimistic.
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