The location of gastrointestinal (GI) ulcer can be implied by the symptoms. People with stomach ulcers usually complain of pain being caused or worsened by food. They also describe the pain as being widespread over the lower abdomen. When someone has a duodenal ulcer the pain is typically described as sharp and burning in nature with a specific point of tenderness. In contrast to stomach ulcers, people with duodenal ulcers usually experience relief of pain with food.
Other symptoms of a duodenal ulcer include a feeling of abdominal pressure, fullness or hunger. People with duodenal ulcers may also be awakened at night due to the normal nighttime peak in acid secretion. It is important to be aware of "alarm symptoms" which can be present in people who have serious complications from peptic ulcer disease (PUD) such as bleeding or people with stomach cancer. These "alarm symptoms" include weight loss, vomiting, back pain, vomit that has the appearance of "coffee grounds" and dark tarry stools.