What is Eosinophil-Driven Disease?
Eosinophil-Driven Diseases (EDDs) are Type 2 Inflammatory Diseases that can take several forms. Elevated eosinophils play a crucial role in EDDs. Eosinophilic immune dysfunction is responsible for the recruitment and activation of eosinophils and can trigger these illnesses.
It is a systemic allergic response due to an overreactive immune response, causing asthmatic problems and other diseases. The immune system, lungs, gut/stomach, and skin can be affected in different ways.
The following video introduces Eosinophil-Driven Diseases EDD/Type 2 inflammation and its association with asthma.
(Below you can read the text of the video in your language)
Types of EDDs
An estimated 30 percent of the U.S. population experience symptoms of Atopic Dermatitis – also known as Eczema. Symptoms usually start within the first five years of life, often the first six months. With time and treatment, as children mature, eczema will often go away – but it sometimes continues into adulthood.
Chronic Spontaneous Urticaria
If urticarial symptoms—redness, hives, and itching—persist much longer than six weeks, it is called chronic spontaneous urticaria. Discomfort can persist for several months or years, sometimes even for decades. Angioedema can also occur, especially in the facial area or on the hands and feet, and in the genital area. Now it is time to investigate the causes more thoroughly, and in this connection, the doctor and patient need not adhere slavishly to the six-week limit. It depends, not least, on the severity of the discomfort.
Eosinophilic esophagitis (EOE) is an allergic/immune condition that affects the esophagus – the tube that takes food from your mouth to your stomach. It is a form of eosinophil-driven disease, along with severe asthma, atopic dermatitis, nasal polyps, and Samter´s Triad. When the stomach is primarily affected, this is called “eosinophilic gastritis”.
Eosinophilic gastroenteritis (EG) is a rare condition that affects the gastrointestinal tract, particularly the stomach and small intestine. Common symptoms of the condition include diarrhea, abdominal pain, and nausea.
Eosinophilic gastrointestinal disease is sometimes called “eosinophilic gastritis” when the stomach is primarily affected, or “eosinophilic esophagitis” when the symptoms mainly affect the esophagus.
Nasal polyps are a type of eosinophil-driven disease in the form of soft, non-cancerous growths that appear in the lining of the passages or sinuses in your nose. Nasal polyps can vary in size. If they’re small, they might not cause any symptoms, and you may be unaware you have them. However, large polyps or multiple clusters of polyps can cause symptoms and even block your nasal passages.
Samter’s Triad (AERD)
Aspirin-exacerbated respiratory disease (AERD), also known as Samter’s Triad, is a complex chronic medical condition involving a combination of three key factors – asthma, aspirin allergy, and nasal polyps.
Severe asthma is a type of asthma that does not respond well to standard asthma treatments. The symptoms by definition, are more intense than regular asthmatic symptoms and can last for prolonged periods. Sufferers of severe asthma often find their symptoms persistent and difficult to control.
Having severe asthma can have a major impact on daily life, affecting everyday habits, work and social life.It can affect both children and adults, and can develop at any age. However, it’s a lot less common than a standard asthma diagnosis, affecting less than 10% of people.