Also known as thyrotropin, a hormone
synthesized and secreted by thyrotrope cells in the anterior pituitary
gland, which regulates the endocrine function of the thyroid
gland. Thyroid-stimulating hormone (TSH) stimulates the thyroid gland
to secrete the hormones thyroxine (T4)
and triiodothyronine (T3).
The production of TSH is inhibited by the production of somatostatin
by the hypothalamus. T3
and T4 also inhibit TSH production and secretion, creating a
regulatory negative feedback loop. The release of TSH is stimulated by the
production of thyrotropin-releasing
|Source: Joost Van Durme, Glycoprotein-hormone Receptor
Information System (http://gris.ulb.ac.be/)
In the digram shown here, pink = TSH receptor extracellular domain, green
= beta subunit of TSH hormone, blue = alpha subunit of TSH hormone.