Repair of Damaged DNA In Vitro by Extracts from Human Cell Lines
In order to maintain the continuity of the genome, organisms devote many enzymes and regulatory proteins to the repair of spontaneous and environmentally induced DNA damage (Friedberg, 1985). One of the principal repair pathways is DNA excision repair, which acts to remove a segment of a damaged DNA strand and replace it with nondamaged nucleotides. The process acts on a remarkable diversity of DNA lesions, including those produced by ultraviolet light (UV) irradiation and by a variety chemical mutagens (Pu et al., 1989; Van Houten, 1990).
KeywordsExcision Repair Xeroderma Pigmentosum Cyclobutane Pyrimidine Dimer Repair Synthesis Xeroderma Pigmentosum Patient
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