Clérambault came from a musical family (his father and two of his sons were also musicians). While very young, he learned to play the violin and harpsichord and he studied the organ with André Raison. Clérambault also studied composition and voice with Jean-Baptiste Moreau. Clérambault became the organist at the church of the Grands-Augustins and entered the service of Madame de Maintenon. After the death of Louis XIV and Guillaume-Gabriel Nivers, he succeeded the latter at the organ of the church of Saint-Sulpice and the royal house of Saint-Cyr, an institution for young girls from the poor nobility. He was responsible there for music, the organ, directing chants and choir, etc. It was in this post that he developed the genre of the "French cantata" of which he was the uncontested master.