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Samuel Hahnemann's Theory of Miasms has traditionally been linked to the three diseases of scabies, gonorrhoea and syphilis and clinical emphasis on miasmatic prescribing has been on the negative picture associated with the destructive nature of each of these diseases. Psora, Sycosis and Luesis, however, also have a positive emphasis which we tend to overlook; namely, that of curiosity and endurance, the desire to grow and succeed, and the ability to break through and overcome obstacles with a focus on regeneration. With the benefit of recent research on the subject of Epigenetics, it's time we took another look at these three miasms to give them a relevant and modern appraisal. It is my contention that Psora is governed by oxytocin, Sycosis by adrenalin, noradrenalin and cortisol and Luesis by insulin. Since oxytocin regulates homeostasis, Psora's role as ‘the engenderer of all disease’ is established according to the amount of oxytocin-receptor priming that occurs in the Primal Period, which spans conception to weaning at the age of four.