MSCs and HCELL molecules track down islet cells and reverse inflammation.
According to a recently published study from the Brigham and Woman’s Hospital, mesenchymal stem cells [MSCs] have the ability to reverse type I diabetes by suppressing the auto-immune attack of islet cells. Although the MSCs cannot be directly injected into the pancreas, the researchers utilized the surface adhesion molecule HCELL to hone the stem cells in on the inflamed islets, allowing them to normalize blood sugar levels without the use of insulin. Continue reading →
The transplantation of adult stem cells into a Type-1 Diabetes animal model has revealed the importance of blood vessels in pancreatic beta cell regeneration.
Researchers led by Dr. Habib Zaghouani from the University of Missouri have developed a potential cure to Type 1 Diabetes by utilizing mesenchymal stem cells [MSCs]. Although researchers anticipated that the MSCs would differentiate into new insulin producing pancreatic beta cells, they discovered that the stem cells fulfilled the more critical function of repairing damaged blood vessels, which in turn facilitated the regeneration of insulin producing pancreatic beta cells and the distribution of insulin across the body. Continue reading →
Stem cells have been differentiated into pancreatic beta cells, providing a potential treatment for Type 1 Diabetes.
Researchers from the Gladstone Institutes have developed a potential treatment for Type 1 diabetes by differentiating stem cells into insulin-producing pancreatic beta cells. These new cells, when transplanted into animal models, lowered abnormally high glucose levels down to a more healthy level in just one week. Continue reading →
In an early stage study recently carried out by the Institute of Kidney Diseases and Research Center (IKDRC), a treatment developed by the IKDRC utilizing Insulin Secreting Cells (ISC), derived from the patient’s own mesenchymal stem cells, shows that the need for insulin doses decreased by an average of 50% when the ISCs were implanted in patients.
Scientists at the Walter and Eliza Hall Institute recently discovered that the pancreas contains stem cells that can be turned into insulin-producing cells. This new research provides hope that patients who currently suffer from type 1 diabetes may one day be able to regrow their own insulin producing pancreatic beta cells. Researchers are thus turning to stem cells to address a defining aspect of Type 1 Diabetes – the destruction of the pancreas while also seeking ways to modulate the patient’s immune system to prevent it from destroying the new, regenerated pancreatic tissue.