European journal of epidemiology, 2014-01-01, Vol.29 (12), p.911-927
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. In total, 9,778 mothers were enrolled in the study. Data collection in children and their parents include questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, Magnetic Resonance Imaging and biological samples. Efforts have been conducted for collecting biological samples including blood, hair, faeces, nasal swabs, saliva and urine samples and generating genomics data on DNA, RNA and microbiome. In this paper, we give an update of the collection, processing and storage of these biological samples and available measures. Together with detailed phenotype measurements, these biological samples provide a unique resource for epidemiological studies focused on environmental exposures, genetic and genomic determinants and their interactions in relation to growth, health and development from fetal life onwards.
Biobank ; Biological and medical sciences ; Biological samples ; Biological Specimen Banks ; Blood ; Cardiology ; Child ; Child, Preschool ; Childhood ; Children ; Cohort ; Cohort studies ; Data Collection - methods ; DNA ; Environment ; Environmental Exposure ; Epidemiology ; Female ; Fetal ; Fetal Development ; Fetus ; General aspects ; Genomics ; Humans ; Infant ; Infant, Newborn ; Infectious Diseases ; Male ; Medical genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Oncology ; Ophthalmology ; Physical Examination - methods ; Population Surveillance ; Predisposing factors ; Pregnancy ; Prospective Studies ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Research Design ; RNA ; Saliva ; Socioeconomic Factors ; Specimen Handling - methods ; STUDY UPDATE ; Surveys and Questionnaires ; Urine
Alma/SFX Local Collection
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