Cumulative probabilities for concentration of single-copy genes in comparable AUs in real (vertical axis) and simulated (horizontal axis) genomes. Simulated genomes are derived from a reconstructed ancestral duplicated genome by random paralog reduction, random gene deletion within paralog pairs, and random rearrangements. Boxed "above/on/below diagonal" figures reproduced in Table 1. Almost all real genomes show significantly more asymmetry or concentration of single-copy genes than the simulated genomes for AUs of the same size.
Sankoff et al. BMC Genomics 2010 11:313 doi:10.1186/1471-2164-11-313