Unfortunately Neurologists are stuck in the “MS as auto immune disease” concept they learned in Medical School. Repeating that idea a zillion times won’t make it true. Research based on a falsehood can only end in failure. Which doesn’t stop Doctors from prescribing up to 10 available DMD’s (Disease Modifying Drugs) for their MS patients even though the drugs won’t stop descent into progressive MS and disability. Professor George Ebers’ research demonstrated this unhappy fact. After honouring him in the spring of 2013, Neurologists closed ranks against him the following autumn for committing the heresy of exposing this truth. (See Ms Cure Enigmas Blog May 23, 2014 Vitamin D, Veins and Epstein Barr Virus).
Let’s add two more CLUES to solve the Multiple Sclerosis Mystery.
I use as my source the Thisisms.com website and find “cheerleader”, “upright doc” among the best resources.
CLUE NUMBER ONE;
Major MS characteristic: HEAT INTOLERANCE, FATIGUE
CAUSE? Overheated brain due to poor brain fluid circulation. Dr. Flanagan “upright doc” explains it well.
In brief, the net effect of heat production in the brain and brain cooling keeps the brain cooler than the rest of the body and is achieved by surrounding and bathing the brain with venous blood that has been cooled outside the cranial vault, by bone and fat acting as insulation, by the veins of the face and scalp through conduction, convection, sweat and evaporation and by cooled venous blood flowing through the cavernous and suboccipital cavernous sinuses cooling incoming blood in the internal carotid and vertebral arteries before it enters the brain. The combined effect of the brain cooling system keeps the temperature inside the vault and brain about two to three degrees cooler than the rest of the body. The effect is important enough that some physical anthropologists attribute the extra-large size of the human brain more to its exceptional cooling capacity than to the increase in arterial blood flow that comes with upright posture. Anthropologists refer to human encephalization due to enhanced brain cooling capacity as the "radiator theory".
It is interesting to note that recent research by Dr. Paulo Zamboni suggests that obstruction of the drainage system of the brain, which he calls chronic cerebrospinal venous insufficiency (CCSVI) can cause multiple sclerosis (MS). Dr. Zamboni attributes the cause of CCSVI to obstruction in the jugular veins (one of the main extracranial drainage routes). As I discuss in my book, it is similarly possible that, chronic craniocervical venous back pressure (CCVBP) due to misalignments and other problems of the upper cervical spine can lead to neurodegenerative processes and subsequent MS similar to CCSVI. In contrast to the internal jugular veins, CCVBP affects the vertebral veins. The cavernous and suboccipital cavernous sinues, as well as most of the brain, drain into two extracranial venous drainage routes. One is the internal jugular veins, the other system empties into the vertebral veins. Thus, in addition to venous outflow, CCSVI due to jugular stenosis and faulty valves, and CCVBP due to upper cervical misalignments can affect brain cooling capacity due their impact on venous outflow and arterial cooling in the cavernous and suboccipital cavernous sinuses. Interestingly, in addition to many other signs and symptoms a common complaint among MS patients is heat intolerance. It is possible that both CCSVI and CCVBP can decrease the cooling capacity of the brain and thus contribute to the heat intolerance seen in many MS patients.”
CONCLUSION. KEEP BRAIN FLUIDS CIRCULATING. (Massage, Energy thérapies, Acupuncture, Body Structure Manipulation, Angioplasty etc??)
CLUE NUMBER TWO. Endothelium (inner lining of vein walls) missing in MS patients. Cause of vein collapse, stenosis and subsequent poor blood circulation?
http://phl.sagepub.com/content/early/20 ... 0.abstract
Professor Zamboni’s team at the Vascular Disease Center compared the condition of the jugular vein walls (endothelium) in 7 MS patients to controls.
Ultrastructure of internal jugular vein defective valves
Objectives To study the ultrastructure of intraluminal defects found in the internal jugular vein by using a scanning electron microscopy.
Methods Using a scanning electron microscopy, intraluminal septa and/or defective valves blocking the flow in the distal internal jugular vein of seven patients were studied together with the adjacent wall and compared with control specimen.
Results The internal jugular veins’ wall showed a significant derangement of the endothelial layer as compared to controls. Surprisingly, no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina.
Conclusions Although the lack of endothelial cells in the internal jugular vein intraluminal obstacles is a further abnormality found in course of chronic cerebrospinal venous insufficiency, our investigation cannot clarify whether this finding is primary or caused by progressive loss of endothelium in relation to altered haemodynamic forces and/or to a past post-thrombotic/inflammatory remodelling.”
What does this imply?
That the endothelium (inner walls) of the veins in MS patients are defective, even missing. If the inner wall is weak or missing, what will prevent the vein from collapsing? Doesn’t that go a long way to explaining the collapsed, kinked veins observed in the sonograms of MS patients? Doesn’t that tend to re-inforce my idea that childhood developmental factors can actually damage the vein walls? If the endothelium requires optimal nutrition, sunlight, vitamins and minerals and a freedom from infection to develop properly, doesn’t that imply that a poor health condition can actually deform the vascular network?
The Zamboni team observed that it is unknown if the endothelium damage CAUSES the poor blood circulation leading to MS, or if the poor blood circulation CAUSES the endothelium stress. Whatever the case, this re-inforces for me the need to strengthen my vein walls through optimal nutrition, supplements and sunlight exposure. Not only must I think about healing the myelin sheath, I must heal the vein walls as well and do whatever necessary to keep the blood circulating. (Future entry. Shouldn’t stem cell therapy work to rebuild the endothelium as well as the myelin sheath rather than seek to reconsitute the immune system?)
The stressed Endothelium issue also suggests caution in undergoing Angioplasty. What if ballooning the jugular vein actually damages the endothelium further? Doesn’t that imply that a collapsed vein will necessitate a stent to remain open? Doesn’t that suggest that even if an MSer has undergone successful angioplasty, she should ensure a strong venous structure through a healthy lifestyle, she can’t let her guard down about diet, vitamins, stress reduction?
It would be helpful if vein specialists (Angiologues) could continue their work unhindered by the Big Pharma/Neurology lobby which promotes the Auto-immune disease theory of MS and the DMD drugs.
Unfortunately May 2012 the FDA imposed restrictions on CCSVI research in the USA which has slowed progress considerably.
After the 27 year son of the Neurosurgeon Dr. David Hubbard was diagnosed with Multiple Sclerosis in 2009, Dr. Hubbard reviewed the literature to conclude 1) that the neuroscience had never demonstrated that MS is an auto-immune disease, and 2) that all the MS drugs are T cell suppressors/killers which may act to reduce the frequency of relapses but do not halt disease progression. His research led him to the Zamboni “liberation therapy” and his son’s eventual successful angioplasty procedure.
Dr. Hubbard’s Hubbard Foundation established a registry which enrolled and treated for CCSVI over 500 patients at 20 sites in the United States. The results of the study of 259 patients at Dr. Hubbard’s San Diego clinic (Drs. Ponec, Goodling and Saxon) was published in the Journal of Vascular and Interventional Radiology in September 2012.
The FDA put a stop to this research in May 2012 until it had approved an Investigational Device Exemption (IDE), meaning that the tools used for angioplasty in other procedures (heart conditions etc) could not be used for CCSVI intervention without approval. After multiple requests for such an exemption, the FDA approved a new registry only in December 2013.
However, the work appears to have stalled. The FDA’s requirements appear so restrictive I believe they are in fact hampering research. The study will not be funded. That is to say each participant must pay for the angioplasty. My objection would be that if I’m going to pay for the procedure, I want all potentially stenosed veins to be treated, not just those under study. Why should a paying volunteer have to meet all the criteria? The FDA restricted the study to 10 sites and 662 patients. In February 2014 7 sites had volunteered. And today (July 28, 2014) not a single site has been added. Also, not a single site has received the “green” go ahead signal. (The Haake MRI protocol – cost in 2011 was $3,500 and the treatment 2011 cost $7,500).
Apparently Neurologists are steaming ahead with their own research trying to discredit CCSVI treatment for MS. (More on this later.)
Dr. Hubbard points out that the basic Professor Zamboni theory was that in MS there is a problem with venous drainage of the white matter of the brain. Zamboni himself used Ultrasound of the neck veins to diagnose CCSVI, a method which has since proven invalid. It is this error the Neurologist’s CCSVI opposition has fixed on to dismiss the theory rather than consider another means of diagnosis. While Dr. Sclafani believes the gold standard for CCSVI diagnosis is the actual angioplasty intervention using the Intravenous Ultrasound (IVUS) to SEE inside the vein, Dr. Hubbard’s study will use the Haake MRI protocol.
(I will finish this entry later by describing the Haake Protocol.)
Tags: MS, Multiple Sclerosis, CCSVI, Dr. Zamboni, Heat Intolerance, MS Fatigue, Endothelium, Dr. Haake