Melatonin supports the synchronized reproduction of parasites. Parasites are attracted towards melatonin producing areas of the body during their reproductive cycles. Secretion of melatonin synchronizes the nocturnal release of microflilaria – the early larval stage of a parasitic nematode worm filarial. It follows that exogenous melatonin administration or the use of Blue Blocker Glasses during the day would also trigger release of microfilaria.
The nightly release of microfilaria into the circulation coincides with the feeding activity of parasites, a synchronization that is presumably an evolutionary adaptation favoring survival and transmission of the parasite.
88% of the cercariae (worm larvae) were shed between 11 a.m. and 3 p.m. and the average pattern is of circadian type, with the average peak at 1 p.m., and representing 27% of the total number of cercariae of the day. The rhythms of emergence are associated with nocturnal production of melatonin.
All worms were found in the distal 55% of the small intestine (ileum). During the night and morning, parasite was heavily concentrated in the jejunum and, during the day, worms are located more distally, with a heavy concentration in the ilium. Parasites have a migratory pattern that occurs with the initiation of gastric activity of the host. Worms move away from the areas producing digestive chemistry when production is initiated after eating. Two hours after feeding worms move towards the food. High fat diets result in a significant decline in worm dry weight, body area and uterine egg counts in worms. Low fat diets are conducive to increased parasite infestation.
Helminthic therapy, an experimental type of immunotherapy, is the treatment of autoimmune diseases and immune disorders by means of deliberate infestation with a helminth or with the ova of a helminth. Helminth therapy is being used as a treatment method for autoimmune and other inflammatory disorders.
There are a few studies highlighting the potential dangers of helminthic therapy. These are rare because as with Blue Blocker Glasses; no one wants to look at the dark side of Helminth therapy, hence few case studies.
Would you like to be advised of the negative potential of any therapy to consider before trying it.
Worms do not honor intestinal boundaries. They are capable of penetrating the intestinal lining. Especially, when overcrowding occurs from excess reproduction, e.g. melatonin stimulates parasite reproduction. This can also cause an obstruction by a large tangled mass of whipworms. Perforation of the ascending colon occurs as the worms expand their territory. How many people do you know that will go back to their social media friends to post something like this?
The good news is that the production and release of reactive oxygen species(ROS) stimulated by melatonin probably prevents most of the damage that normally occurs in parasitic infestation, e.g., eosinophil infiltration. This will also make the person with the parasitic overgrowth to be unable to feel any discomfort from the parasites.