Action And Clinical Pharmacology: Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures.
Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have been found in man following oral use. Percutaneous absorption, if it occurs at all, is insignificant.
Indications And Clinical Uses: A potent antibacterial agent active against a wide range of organisms. Recommended for swabbing wounds and burns and in obstetrics.
Contra-Indications: For patients who have previously shown a hypersensitivity reaction to chlorhexidine. However, such reactions are extremely rare. tag_WarningWarnings
Manufacturers’ Warnings In Clinical States: For external use only. Keep out of the eyes and avoid contact with brain, meninges, or middle ear. Do not inject. Do not use in body cavities.
If chlorhexidine solutions come into contact with eyes, wash out promptly and thoroughly with water.
Discard any surplus solution immediately after use since sterility can no longer be assured.
Do not use the solution in the eyes before or after ophthalmic surgery. If accidental contact is suspected, wash thoroughly with sterile water before starting surgical procedure. Do not use solution with alcohol (e.g. 450 mL) on deep wounds and deep burns or in obstetrics. Do not use solution with alcohol for eye irrigation. On broken skin, use only sterile solutions.
Precautions: Hypochlorite bleaches may cause brown stains to develop in fabrics which have previously been in contact with chlorhexidine solutions. Use a perborate bleach instead. Hibidil is incompatible with anionic agents.
Adverse Reactions: Irritative skin reactions can occasionally occur. Generalized allergic reactions to chlorhexidine have also been reported but are extremely rare.
Symptoms And Treatment Of Overdose: Symptoms and Treatment: Accidental or deliberate poisoning: Accidental ingestion: Chlorhexidine taken orally is poorly absorbed. Treat with gastric lavage using milk, raw egg, gelatin or mild soap. Employ supportive measures as appropriate.
Accidental i.v. infusion: Blood transfusion may be necessary to counteract hemolysis.
Dosage: Apply undiluted.
Availability And Storage: Each mL of sterile aqueous solution contains: chlorhexidine gluconate 0.05% w/v. Nonmedicinal ingredients: isopropyl alcohol and water. Parabens-, sulfites- and tartrazine-free. Plastic bottles of 450 mL.
Each mL of sterile solution contains: chlorhexidine gluconate 0.05% w/v. Nonmedicinal ingredients: water. Alcohol-free. Unit-dose packages of 30 mL, boxes of 10.
Store at temperature not exceeding 25°C. Protect from light. Protect from freezing.
HIBIDIL® 1:2000 Zeneca Chlorhexidine Gluconate Antiseptic