Spinal cord injuries
Cannabinoids have been shown to be effective in reducing spasticity and reports by individuals with these injuries have revealed a beneficial effect from marijuana use. Strokes Extracts from marijuana plants could have some efficacy in preventing brain damage after stroke, according to a team led by the British-born biologist Aidan Hampson, at the U.S. National Institute for Mental Health, in Maryland, they discovered that THC and cannabidiol each act to prevent damage to brain tissue under laboratory conditions.
Chronic pain remains a significant problem for many with spinal cord injury. Recent data from the national Model Spinal Cord Injury Systems indicate a pain prevalence ranging from 81% at 1 year after injury to 82.7% at 25 years.
Ischemic stroke has become one of the leading causes of death and severe disability, it is caused by a prolonged interruption of the arterial blood flow in the brain characterised by residual tissue infarction.
Role of Cannabinoid Receptors after Ischemic Stroke
“The endocannabinoid system is considered as a major modulator of the cerebral blood flow, neuro-inflammation, and neuronal survival. Despite some controversies, the activation of CB2 receptor has been shown to reduce cerebral injury associated with acute post-stroke inflammation and leukocyte infiltration. On the other hand, the direct role of CB1 in neuronal protection has not been clarified yet. Evidence from animal models and in vitro studies suggests a global protective role for cannabinoid receptors agonists in ischemic stroke”
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Therapeutic Potential of CBD in Ischemic Stroke
“Accumulating data now suggest that cannabinoid CB1 receptors contribute to neuroprotection through anti-excitotoxicity, the phosphatidylinositol-3 kinase/Akt pathway, and hypothermia. We have reported that the neuroprotective and hypothermic effects of delta9-THC were related to CB1 receptors. CBD has also been described as protective against global and focal ischemic injury”
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