The human genome is exposed to potentially deleterious genotoxic events during every cell division cycle. This endogenous source of DNA damage results from cellular metabolism or routine errors in DNA replication and recombination. In addition, cellular and organismal exposure to exogenous genotoxic agents such as ionizing radiation, ultraviolet light, oxidative stress, and chemical mutagens, may lead to a variety of nucleotide modifications and DNA strand breaks. Several assays are available to assess the mechanisms underlying DNA damage and repair.
Assays that detect Poly ADP-ribose (PAR) and PAR Polymerase (PARP).
A simple and effective method for evaluating DNA damage in single cells.
DNA Damage and Repair Enzymes can be used in vitro to detect specific forms of DNA damage.
A simple and fast plate-based method for assaying Superoxide Dismutase activity.
A plate-based immunoassay designed to detect and quantify 8-hydroxy-2’-deoxyguanosine (8-oxo-dG).
CometAssay is a trademarks of Trevigen, Inc.