hypertension...Inhibition of carbonic anhydrase produces diuresis (urine formation). Subsequently, many sulfanilamide-like compounds were synthesized and screened for their ability to inhibit carbonic anhydrase. Acetazolamide, which was developed by scientists at Lederle Laboratories (now a part of Wyeth Pharmaceuticals, Inc.), became the first of a class of diuretics that serve as carbonic anhydrase...
myotonia...myotonia congenita; however, the drug must be used with caution because it can interfere with cardiac function. Quinine and phenytoin have also been used to alleviate symptoms of myotonia congenita. Acetazolamide may be used for potassium-aggravated myotonia and other myotonias caused by mutations in SCN4A. Individuals with such conditions may also benefit from mexiletine.
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