Obese people who lose a significant amount of weight could slow down the degeneration of their knee cartilage, but only if they lose weight through diet and exercise or diet alone, according to researchers.
“Once cartilage is lost in osteoarthritis, the disease cannot be reversed,” says Alexandra Gersing, MD, from the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She is lead author of the study, which was presented recently during the Radiological Society of North America (RSNA) annual meeting.
In the study, per a media release from RSNA, Gersing and colleagues investigated cartilage degeneration and joint abnormalities over the course of 96 months in overweight and obese individuals who maintained stable weight and who lost weight via differing regimens.
The researchers studied 760 men and women with a body mass index of greater than 25 from the Osteoarthritis Initiative, a nationwide research study focused on the prevention and treatment of knee osteoarthritis. The patients either had mild to moderate osteoarthritis or risk factors for the disease. Patients were divided into a group of 380 patients who lost weight, and a control group of 380 patients who lost no weight. The weight-loss group was further segmented by weight loss method: diet and exercise, diet alone, and exercise alone. The researchers used MRI to quantify knee osteoarthritis at the beginning of the study, at 48 months and at 96 months.
Cartilage degeneration was significantly lower in the weight loss group, compared to the control group over the 96 months. However, this finding was only present among the patients who lost weight through diet and exercise or diet alone. Although patients who only exercised lost as much weight as patients who dieted alone or dieted and exercised, weight loss through exercise alone showed no significant difference in cartilage degeneration, compared to the group who lost no weight.
“These results add to the hypothesis that solely exercise as a regimen in order to lose weight in overweight and obese adults may not be as beneficial to the knee joint as weight loss regimens involving diet,” Gersing states.
[Source(s): Radiological Society of North America, Science Daily]