Skin extrinsic ageing
This is the accumulated damage derived from external assaults. According to Harman’s free radical theory of ageing, organisms age because cells accumulate free radical damage with the passage of time. UV and free radicals induce inflammation and damage cell content such as DNA, the extracellular matrix as well as the cell membranes as well as increasing cell proliferation resulting in premature aging
Preventing oxidative damage may delay premature ageing
Skin intrinsic ageing
This is the natural and programmed ageing in the skin. Based on Hayflick’s Limit Theory of Ageing cells have a limited capacity to replicate and as they advance in replication number, they age. Prof. Hayflick theorized that the human cells ability to divide is limited to approximately 50-times, after which they simply stop dividing and die.
The theory was accommodated with the discovery of the cell internal biological clock - the telomeres.
A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from destruction. Each time the cells replicates the telomeres are shortened. The telomere shortening mechanism normally limits cells to a fixed number of divisions which comes in line with Hyflick’s Limit theory and observations. Studies suggest that this is responsible for ageing on the cellular level and sets a limit on cells lifespan.
Maintenance of telomeres via slow down of cell proliferation may be one way to maintain youth.
2009 Nobel Prize for Medicine was awarded for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase
It is believed that slowing down cell proliferation preserves the cell youth capital, thereby delay the ageing process
Anti-ageing with DORMINs technology
The slowing of cell proliferation can be accomplished via the concept of dormancy. Dormancy is a natural state that plants and some animals enter to protect themselves from unfavourable environmental and growth conditions.
During dormancy cell proliferation and growth is inhibited. Flower bulbs are a good example: they go dormant through the winter season and emerge as beautiful, rejuvenated blossoms in the spring.
Inhibition of cell proliferation during dormancy is achieved through DORMINs. However, the chemical nature of these entities varies between plants and organisms, which is why it has been difficult to determine their mechanism of action beyond reversing growth arrest. Once dormins are removed, cell growth resumes; thus dormins are a favourable approach to treat intrinsic aging since they are reversible cell proliferation inhibitors. Further, it is known3 that UV and oxidative stress can cause enhanced proliferation leading to premature ageing. Therefore, slowing this proliferation process could not only preserve the cell youth capital, but also slow the effects of premature ageing.
DORMINS technology platform and products (a patented technology of IBR Ltd) comes to address intrinsic aging via one of the suggested mechanisms, ie SLOWING DOWN CELL PROLIFERATION TO SLOW DOWN AGING.
The platform includes different products that carry in common the DORMINs mechanism of slowing down ageing, but, differ from each other in there composition and additional benefits.