Etoricoxib is a type of drug called a non-steroidal anti-inflammatory drug (NSAID). It works by stopping the production of compounds called prostaglandins in the body. Prostaglandins have a number of effects on your body, including causing inflammation.
Therefore, Etoricoxib can help to reduce pain and inflammation by stopping the production of prostaglandins. This is which it is usually used to relieve painful inflammatory conditions, such as arthritis.
Brand Names and Doses
Etoricoxib is available as tablet to be swallowed, under the brand name Arcoxia. The brand name is simply the name of the medication that contains etoricoxib given by the pharmaceutical company that produces it. .
There are currently three different doses of Etoricoxib available: 30mg, 60 mg and 120 mg.
What type of drug is it?
Etoricoxib is a type of drug known as a non-steroidal anti-inflammatory drug (NSAID), which is a group of drugs that all work in a similar way. Other examples of NSAIDs include:
Etoricoxib is a special type of NSAID, which we call a COX-2 selective NSAID. This is because it specifically blocks COX-2 (and not COX-1), which helps to reduce pain and inflammation with a lower risk of side effects.
It has a long half-life, which means that stays in your body for a longer time after taking a dose. In fact, almost half of the original dose is still in your body 24 hours after taking a dose! As a result, you can take a dose less often than for other NSAIDs, usually once a day.
What is Etoricoxib used for?
Etoricoxib is often used to help relieve symptoms of pain and inflammation caused by various health conditions such as:
- Muscular injury pain
How does it work?
Etoricoxib works by inhibiting COX-2, which is needed to produce prostaglandins in your body.
You have many different types of prostaglandins in your body, and there are some in almost every tissue. They each have different effects on your body, such as to cause your blood vessels to relax and widen, the platelets in your blood to come together to form a clot, or the tissues in your body to become inflamed.
Unlike other general NSAIDs that block both COX-1 and COX-2, etoricoxib specifically blocks the action of COX-2. Inflammation is mostly caused by the prostaglandins that produced with the help of COX-2. Therefore, etoricoxib has a more targeted effect to reduce pain and inflammation, with fewer side effects from the COX-1 related prostaglandins, such as blood clotting and hypertension.
Even though etoricoxib has a more targeted effect than other NSAIDs because it only affects COX-2, you may still experience some side effects. These may include:
This is not a complete list of side effects, but just some of the most common. Please see the etoricoxib information leaflet for more detailed information.
Etoricoxib can interact with many other medications when they are used in together, including:
These medications can often be used together, but your doctor should be aware that you are taking both medications so that they can adjust the dose as needed to ensure they are safe and effective.
There are some people who may need to avoid using Etoricoxib, or use it with caution, because they may be at risk of side effects due to the medication.
Peptic ulcers or GI bleeding:
Etoricoxib is not often used for people who have a history of gastrointestinal bleeding or peptic ulcers. While it is less likely than other NSAIDs to cause peptic ulcers or gastrointestinal bleeding, they can still occur.
If it is used, a combination with a medication to help prevent gastrointestinal problems, such as esomeprazole or pantoprazole, is recommended.
Etoricoxib may increase the risk of bleeding or thrombosis because the antiplatelet effect of the prostaglandins may be reduced. This is less likely with etoricoxib than other NSAIDS, although it can still occur.
Etoricoxib may cause retention of sodium and fluid in the body, which can make hypertension and heart failure worse.It should not be used if you have heart failure, angina, peripheral artery disease or cerebrovascular disease.
Etoricoxib may increase the risk of bronchospasm and cause symptoms of asthma to worsen. Some people with asthma can use them without any problems, but it is best to use a low dose and watch for signs of worsening asthma if you are using it for the first time.
Inflammatory Bowel Disease (IBD):
Etoricoxib may cause symptoms of inflammatory bowel disease to get worse.
Etoricoxib can cause renal impairment is some people, particularly when used in combination with some other medications. If you already have some renal impairment, an NSAID may not be the best choice for you.
Pregnancy and Breastfeeding
Etoricoxib is not usually recommended for women who are pregnant or trying to conceive. This is because it can interfere with fertility and the development of the fetus.
For women planning to become pregnant, it can prevent or delay ovulation, so that the woman is less likely to conceive. Additionally, using etoricoxib during pregnancy, particularly at the time of conception, is linked to a higher risk of miscarriage. It may also cause other problems later on in the pregnancy and should be avoided.
For women who are breastfeeding, etoricoxib is considered safe to use.