Health Evaluation through Logical Processing (HELP) was the first hospital information system to integrate clinical data accumulation and clinical decision support. The real addition of this system was using the computer to aid decision-making, such as recognition of cardiac tamponade, by analysis of patient results. One trial suggested the the program had a 94% success rate of choosing an appropriate antibiotic regimen compared to a 77% success rate for physicians [Desouza KC 2002]. It also supports selection of appropriate antibiotics in case of infectious diseases. Clinical decision support also predicts and prevents many adverse drug events (ADE's).