[Summary of the course] In this course, in order to acquire the ability to draw up a synthetic plan of the simple organic compounds, advanced contents of (1) chemistry of aromatic compounds, (2) chemistry of compounds containing oxygen and sulfur, (3) stereochemistry, and (4) substitution and elimination reactions will be explained to the students who studied Organic Chemistry III (Aromatic Compounds) and Organic Chemistry IV (Nucleophilic Substitution).
[Aim of the course] Aromatic compounds are the compound group found widely in bioactive substances or organic materials, and it is
extremely important to understand their property, reactions, and synthesis. The stereochemistry is important in understanding biochemistry as well as organic chemistry. In this course, students will acquire advanced practical skills and problem-solving skills through practice problems and interpretation of the above (1)-(4).
By the end of this course, students acquire the following abilities to:
(1) Explain advanced contents of chemistry of aromatic compounds.
(2) Explain advanced contents of chemistry of compounds containing oxygen and sulfur.
(3) Explain advanced contents of stereochemistry.
(4) Explain advanced contents of substitution and elimination reactions.
(5) Draw up a synthetic plan of the target compound, based on the above (1), (2), (3), and (4).
Benzene, aromaticity, electrophilic aromatic substitution reactions, oxidation, reduction, alcohols, phenols, ethers, epoxides, thiols, sulfides, enantiomers, optical activity, phenomena of isomerism, alkyl halides, organometallic chemistry, nucleophilic substitution reactions, SN2 reactions, SN1 reactions, elimination reactions
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||✔ Practical and/or problem-solving skills|
This course will proceed in the following order: (1) chemistry of aromatic compounds, (2) chemistry of compounds containing oxygen and sulfur, (3) stereochemistry, (4) substitution and elimination reactions. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.
|Course schedule||Required learning|
|Class 1||Chemistry of benzene||Explain advanced contents of chemistry of benzene.|
|Class 2||Chemistry of alcohols and phenols||Explain advanced contents of chemistry of alcohols and phenols.|
|Class 3||Chemistry of ethers and epoxides, and thiols and sulfides||Explain advanced contents of Chemistry of ethers and epoxides, and thiols and sulfides.|
|Class 4||Optical activity and phenomena of isomerism||Explain advanced contents of Optical activity and phenomena of isomerism.|
|Class 5||Synthesis and reactions of alkyl halides||Explain advanced contents of synthesis and reactions of alkyl halides.|
|Class 6||Substitution reactions||Explain advanced contents of substitution reactions.|
|Class 7||Elimination reactions||Explain advanced contents of elimination reactions.|
|Class 8||Practice problems and interpretation for confirming the level of understanding||Solve advanced practice problems by accurate understanding of the above all lectures.|
McMurry Organic Chemistry, international edition of 8th revised edition (Cengage Learning) ISBN-13: 978-0840054531
Study Guide with Student Solutions Manual for McMurry's Organic Chemistry, 8th edition (Cengage Learning) ISBN-13: 978-0840054456
Practice problems and interpretation for confirming the level of understanding (85%), level of class participation (15%) (The level of class
participation will be calculated by discussion, small examination and so on in the lecture.)
The condition of the study will not be made, but it is desirable to study Organic Chemistry III (Aromatic Compounds) and Organic Chemistry IV (Nucleophilic Substitution).