Datasets:

ClarusC64
/

clinical-therapeutic-pathway-trajectory-manifold-construction-v0.1

id stringclasses 10 values	pathway_anchor stringclasses 10 values	patient_profile stringclasses 10 values	baseline_state_vector stringclasses 10 values	timepoints stringclasses 7 values	interventions stringclasses 10 values	state_vector_series stringclasses 10 values	modality_delta_series stringclasses 10 values	trajectory_shape_features stringclasses 10 values	manifold_summary_label stringclasses 5 values	evidence_trace stringclasses 10 values	failure_signature stringclasses 3 values	constraints stringclasses 1 value	gold_checklist stringclasses 10 values
TPM-TMC-001	RA biologic initiation	48F, RA active	CRP=38; pain=8; PRO_fatigue=8; US_synovitis=high	W0,W2,W6,W12	W0 start biologic; W6 dose optimize	W0{CRP38,pain8,fatigue8,US_high}->W2{CRP22,pain6,fatigue7,US_mid}->W6{CRP14,pain4,fatigue5,US_mid}->W12{CRP8,pain3,fatigue4,US_low}	W0-2{CRP-16,pain-2}->W2-6{CRP-8,pain-2}->W6-12{CRP-6,pain-1}	monotonic_multimodal_gain; low_volatility	smooth_improvement	All modalities improve with consistent slope	none	Under 200 words.	1 movie series
TPM-TMC-002	IBD steroid bridge then biologic	32M, IBD flare	calprotectin=1200; stool_freq=9; weight=-4kg; MRI_inflam=high	D0,D7,D21,D56	D0 steroids; D21 start biologic	D0{cal1200,stool9,wt-4,MRI_high}->D7{cal700,stool6,wt-3,MRI_high}->D21{cal650,stool6,wt-3,MRI_mid}->D56{cal180,stool3,wt-1,MRI_low}	D0-7{cal-500,stool-3}->D7-21{cal-50,flat}->D21-56{cal-470,stool-3}	plateau_then_jump; modality_lag_imaging	plateau	Early partial response then long plateau until biologic shift	none	Under 200 words.	1 plateau signature
TPM-TMC-003	Depression CBT pathway	29F, MDD	PHQ=20; sleep=4.5h; function=3/10	W0,W4,W8,W12	W0 CBT start	W0{PHQ20,sleep4.5,func3}->W4{PHQ17,sleep5.2,func4}->W8{PHQ14,sleep6.0,func6}->W12{PHQ10,sleep6.7,func7}	W0-4{PHQ-3}->W4-8{PHQ-3}->W8-12{PHQ-4}	steady_psych_gain; low_volatility	smooth_improvement	Psych measures improve steadily over sessions	none	Under 200 words.	1 longitudinal
TPM-TMC-004	Post-op physio after knee scope	57M, knee arthroscopy	pain=7; ROM=60; steps=400; sleep=5.5h	D3,D10,D21,D42	D3 physio start; D21 intensify	D3{pain7,ROM60,steps400,sleep5.5}->D10{pain6,ROM70,steps700,sleep5.6}->D21{pain6,ROM72,steps720,sleep5.2}->D42{pain4,ROM92,steps1900,sleep6.4}	D3-10{ROM+10,steps+300}->D10-21{flat}->D21-42{ROM+20,steps+1180}	plateau_then_jump; mobility_lag	plateau	Mobility stalls then jumps after intensification	none	Under 200 words.	1 detects stall
TPM-TMC-005	Hypertension med titration	63F, HTN	SBP=172; DBP=96; dizziness=0	W0,W2,W6,W12	W0 start ACEi; W2 add thiazide; W6 reduce dose	W0{SBP172,DBP96,diz0}->W2{SBP156,DBP90,diz1}->W6{SBP138,DBP84,diz2}->W12{SBP142,DBP86,diz0}	W0-2{SBP-16}->W2-6{SBP-18,diz+1}->W6-12{SBP+4,diz-2}	nonlinear_tradeoff; side_effect_loop	mixed_uncertain	BP improves then rebounds with dose change while dizziness resolves	tradeoff	Under 200 words.	1 mixed tradeoff
TPM-TMC-006	Migraine preventive trial	35F, migraine	attacks_per_week=4; function=5/10; anxiety=6	W0,W4,W8,W12	W0 beta blocker; W8 stop due fatigue	W0{att4,func5,anx6}->W4{att2,func6,anx5}->W8{att2,func4,anx6}->W12{att4,func5,anx6}	W0-4{att-2}->W4-8{func-2}->W8-12{att+2}	on_off_coupled; paradox_side_effect	oscillatory	Benefit holds while on, then relapse after stop	none	Under 200 words.	1 on off coupling
TPM-TMC-007	Autoimmune fatigue with LDN	41F, multi-system	CRP=9; fatigue=8; pain=6; cognition=5/10	W0,W4,W12	W0 LDN start	W0{CRP9,fat8,pain6,cog5}->W4{CRP7,fat6,pain5,cog6}->W12{CRP6,fat5,pain4,cog7}	W0-4{fat-2,cog+1}->W4-12{fat-1,cog+1}	smooth_multidomain_gain	smooth_improvement	Small consistent gains across domains	none	Under 200 words.	1 multi-domain
TPM-TMC-008	COPD exacerbation pathway	68M, COPD	FEV1=38%; dyspnea=8; CRP=22; CXR=hyperinflation	D0,D3,D10,D30	D0 antibiotics+steroids; D10 rehab start	D0{FEV38,dysp8,CRP22,CXR_hyper}->D3{FEV40,dysp7,CRP14,CXR_hyper}->D10{FEV42,dysp6,CRP10,CXR_hyper}->D30{FEV45,dysp5,CRP8,CXR_hyper}	D0-3{CRP-8}->D3-10{dysp-1}->D10-30{FEV+3}	modality_lag_imaging; steady_gain	smooth_improvement	Inflammation drops early; function improves later	none	Under 200 words.	1 lag
TPM-TMC-009	Cancer chemo cycle	59F, breast cancer	tumor_marker=high; fatigue=6; neutrophils=normal	C1,C2,C3,C4	C1 chemo start; C2 dose reduce	C1{markerHigh,fat6,neutN}->C2{markerMid,fat7,neutLow}->C3{markerMid,fat6,neutLow}->C4{markerLow,fat6,neutMid}	C1-2{marker-1,neut-1}->C2-4{marker-1,neut+0.5}	tradeoff_toxicity; partial_response	mixed_uncertain	Marker improves but toxicity constrains dosing	toxicity	Under 200 words.	1 tradeoff
TPM-TMC-010	Post-viral syndrome pathway	34F, post-viral	HRV=38; fatigue=9; steps=800; mood=4	W0,W2,W6,W12	W0 pacing; W6 add sleep protocol	W0{HRV38,fat9,steps800,mood4}->W2{HRV35,fat9,steps700,mood4}->W6{HRV40,fat8,steps900,mood5}->W12{HRV48,fat6,steps1800,mood6}	W0-2{HRV-3}->W2-6{HRV+5}->W6-12{steps+900,fat-2}	decline_then_rebound; intervention-linked	deterioration	Early worsening then recovery after added intervention	none	Under 200 words.	1 decline rebound